武汉地区25家医院纳洛酮应用情况调查

Application Investigation of Naloxone Used in 25 Hospitals in Wuhan

目的通过调查纳洛酮的使用状况,促进其在临床上的合理使用。方法通过长江流域用药分析系统,对纳洛酮在武汉地区25家医院的使用信息进行回顾性调查分析。结果0.4mg的纳洛酮使用金额3年内有所下降,其它规格如0.8mg,1mg,2mg,4mg则呈上升趋势,总用量显示大幅度增长。结论已有文献报道的纳洛酮的新的临床作用越来越广泛,使其用量剧增,但临床医生在使用时仍应严格掌握其适应症,注意其可能出现的不良反应。作为法定标准的药品说明书也应根据严谨的临床实验研究进行更新,给医生提供详细的用药依据,以保证临床用药安全。

Objective To promote rational use of naloxone in clinical practice by investigating its use conditions.Methods The use information of naloxone in 25 hospitals in Wuhan were investigated retrospectively,using the Yangtze River basin drug analysis system.Results The use amount of naloxone with the specifications 0.4mg declined in three years,but other specifications,such as 0.8mg,1mg,2mg,and 4mg increased.As for the total amount,it showed a substantial growth.Conclusion With the more clinical role in the literature,the usage amount of has been raised greatly.But clinicians should strictly control the use of naloxone,paying attention to the possible adverse reactions.As the legal standard of medicine instructions,it should be updated according to the strict clinical studies which can provide a detailed basis for the doctor to ensure the safety of clinical medicine.