丙泊酚联合米索前列醇在无痛人流中的应用

The Application of Propofol and Misoprostol for Painless Induced Abortion

目的探讨用丙泊酚行无痛人流术前阴道放置米索前列醇对宫颈的软化、扩张作用,同时弥补丙泊酚镇痛不足,减少其用量及副作用。方法对我院2008年9月至2009年9月早孕妇女200例,随机分为2组,每组100例。试验组术前1～2h阴道穹隆置入米索前列醇0.2mg;对照组不使用任何软化宫颈的药物。2组丙泊酚用量按公斤体重计。观察2组宫颈扩张,出血量,镇痛效果,呼吸抑制及血压下降情况。结果试验组宫颈扩张明显优于对照组(P<0.05),阴道出血量明显小于对照组(P<0.01)镇痛效果优于对照组(P<0.01)。结论试验组宫颈软化、易扩张,宫颈损伤小,出血少,镇痛完善,麻药用量少,呼吸抑制发生率低。

Objective Observe efficient result about the use of propofol and misoprostol during painless artificial abortion.Methods Selected 200 cases of early pregnancy women who wanted artificial abortion then divided by randomly into two groups,The experiment group is placed in Vagina Fornix with 0.2mg of Misoprostol two hours before surgical while without any cervical ripening drug in comparing group.Same Ropofol protocol is adopted in both groups.Results Cervical dilatation,shorter operative time,less anaesthetic medicine and less side-effect in experiment groups（P0.01）than the other.Conclusion With 0.2mg of Misoprostol placed in vagina Fornix 1～2 hours before surgical,the cervix is softened and easy to enlarge which improves surgical quality,shorten surgical time and reduce anaesthestic usage.