矽肺遗传易感性的病例—对照研究

Case control study of genetic susceptibility of silicosis

目的探讨ＡＢＯ血型、个性、ＨＬＡＤＱ与矽肺易感性的关系。方法以某钢铁公司１９９７年１２月确诊的Ⅰ期矽肺男性患者为对象。与病例同性别、同工种、在同一车间工作、开始接尘时间及累积接尘工龄相差不超过２年、年龄相差不超过５岁、于１９９７年１２月拍片证实非矽肺接尘工人为对照。病例与对照按１∶１配比。进行了ＡＢＯ血型分布、艾森克个性问卷调查和ＨＬＡＤＱ水平测定。结果矽肺组与对照组比较，血型分布无明显差异；矽肺组外倾性格的人所占比例高于对照组，ＨＬＡＤＱ水平低于对照组。结论ＡＢＯ血型与矽肺易感性无明显关联；外倾性格的人、ＨＬＡＤＱ水平较低者可能对矽肺易感。

Objective To study the relationship of ABO blood groups,personality and HLA DQ to susceptibility of silicosis. Methods 92 male patients with I period of silicosis diagnosed in December 1997,and 92 male workers of the same type of work in production and working in the same workshop as control were investigated.The control workers were also proved by X ray in Dec.1997 that they did not suffer from silicosis.The difference of age and cumulative exposure time between the case and control were not over five years and two years respectively.The silicosis group matched with the control according to 1∶1.The ABO blood groups were identified by a means of the glass coagulation the personality was investigated by Esink questionnaire and HLA DQ was measured by indirect immuno fluoroscopy. Results There was no difference in distribution of blood groups between the case and control group.The percent of extroversion personality in silicosis was higher than that of control.The level of HLA DQ in silicosis was obviously lower than control. Conclusion There was no obvious relationship between susceptibility of silicosis and ABO blood groups.The workers of extroversion personality and lower level of HLA DQ may be susceptible to silicosis.