细胞间粘附分子-1与亚临床绒毛膜羊膜炎的关系探讨

Relationship between in intercellular adhesion molecule-1(CAM-1)with subclinical chorioamnionitis

目的研究细胞间粘附分子-1(ICAM-1)与亚临床绒毛膜羊膜炎的关系。方法采用免疫组织化学方法检测ICAM-1在胎膜早破组及相对应孕周末破膜妊娠组(对照组)胎膜中的表达,同时将所有病例的胎膜进行病理组织学检查。结果 ICAM-1在胎膜早破组中的表达明显高于对照组,两者差异有显著意义(P<0.05),而且在发生绒毛膜羊膜炎的研究组中表达更高,两者差异有极显著意义(P<0.01),胎膜早破组中绒毛膜羊膜炎的发生率(64.15%)明显高于对照组(20.00%)。结论细胞间粘附分子-1在胎膜早破组中的表达明显增高,其表达程度与感染程度相关。

Objective To study the relationship between intercellular adhesion molecule-1 （CAM-1 ） with subclinical chorioamnionitis.Methods The expression of ICAM-1 in the fetal membrane were detected in premature rupture of membranes group and the corresponding gestational weeks group without membranes rupture （control group ） by immunohistochemisry testing method,while all fetal membranes were examined pathologically.Results The expression of I CAM-1 in premature rupture of membranes group was significantly higher than the control group,and there was a significant difference between two groups （P0.05）,and it show higher expressio in the case of cborioamnionitis in the study group,the difference was significant （P0.01）,the incidence of chorioamnionitis in the premature rupture of membranes group （64.15%） was significantly higher than control group （20.00%）.Conclusion There was obviously expression of ICAM-1 in the premature rupture of membranes group and its degree was correlated with the degree of infection.