舍曲林联合尼莫地平治疗脑卒中后抑郁的疗效研究

Efects of Sertraline Combined with Nimodipine on Post-stroke Depression

目的探讨舍曲林联合尼莫地平治疗脑卒中后患者抑郁状态的疗效。方法将115例脑卒中后抑郁患者随机分为观察组63例和对照组52例,观察组患者给予舍曲林+尼莫地平治疗,对照组患者单纯给予舍曲林治疗,在治疗前和治疗8周后分别用汉密尔顿抑郁量表(HAMD)、简易精神状态检查量表(MMSE)、临床神经功能缺损量表(CSS)、改良Barthel指数(MBI)评价两组患者的疗效。结果两组患者疗效间差异有统计学意义(P<0.01),治疗后两组患者的HAMD、MMSE、CSS、MBI评分间差异均有统计学意义(P<0.05);两组患者治疗前、后组内比较HAMD、MMSE、CSS、MBI评分间差异有统计学意义(P<0.05)。结论舍曲林联合尼莫地平治疗脑卒中后抑郁有较好疗效,而且能够明显改善患者的认知能力和神经功能,提高其日常生活活动能力。

Objective To explore the effect of sertraline combined with nimodipine on post - stroke depression. Methods One hundred fifteen post - stroke depression patients were randomized into groups observation （ n = 63 ） and control （ n = 52 ）. Observation group were given treatment of sertraline and nimodipine, control only sertraline. Hamilton Depression Rating Scale （ HAMD）, mini - mental state examination （ MMSE）, clinical neurological deficit scale （ CSS）, Barthel index （BI） were used to evaluate the efficacy in 2 groups. Results After 8 weeks of treatment, the total effective rates of groups observation and control were 82. 5%, 59.6%, respectively, the difference was significant （P 〈 0.05 ）. The scores of HAMD and MMSE increased in 2 groups after treatment （P 〈 0. 05 ）. Barthel index, CCS scores were lower in observation group than in control, the difference was significant （ P 〈 0. 05）. Conclusion Sertraline combined with nimodipine, of a relatively good effect in treatment of post- stroke depression, can improve obviously the cognitive ability and neural function and patients＇ activities of daily living.