酒精性脂肪肝患者行为干预的效果研究

Efficacy Analysis of Behavior Intervention for Alcoholic Fatty Liver

目的探讨行为干预对酒精性脂肪肝的影响。方法选择127例酒精性脂肪肝患者,对其进行有关饮酒危害性的早期健康教育和行为干预,3个月后随访,对比分析干预前后患者的饮酒量、饮酒频度以及肝功能,随访1年后观察超声图像及肝脏超声检测指标的变化。结果(1)127例酒精性脂肪肝患者干预前后饮酒量、饮酒频度间差异有统计学意义(P<0.05)。(2)患者干预后血清丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、谷氨酰转肽酶(GGT)水平较干预前显著降低,差异有统计学意义(P<0.05)。(3)干预后患者肝左叶厚度、肝右叶最大斜径、门静脉主干内径较干预前显著降低,门静脉主干最大血流速度较干预前显著增加,差异均有统计学意义(P<0.05)。(4)行为干预前后患者脂肪肝严重程度间差异有统计学意义(P<0.05)。结论对酒精性脂肪肝进行早期行为干预,可以显著减少患者的饮酒量和饮酒频度,减少与饮酒相关的肝损害的发生。

Objective To explore the influence of behavior intervention on alcoholic fatty liver.Methods One hundred twenty-seven alcoholic fatty liver patients were given early health education on drinking dangers and behavior intervention.After 3 months,follow-up was conducted to analyze their alcohol consumption,frequency and liver function before intervention and after.Ultrasound imaging and the changes of liver ultrasound testing indicators were observed after 1 year of follow-up.Results There was significant difference in alcohol consumption and frequency between pre-and post-interventions in 127 alcoholic fatty liver patients （P〈0.05）.The levels of serum alanine aminotransferase （ALT）,aspartate aminotransferase （AST）,glutamyl-GGT （GGT） significantly reduced after intervention （P〈0.05）.The left liver lobe thickness,the largest oblique diameter of right liver lobe,the portal vein diameter decreased,the largest portal vein blood flow velocity increased as compared with pre-intervention,the difference was significant （P〈0.05）.There was significant difference in severity of alcoholic fatty liver between pre-and post-interventions （P〈0.05）.Conclusion Behavior intervention can reduce alcohol consumption and frequency,thus to decrease liver injury.