摘要
目的探讨胃切除术对大鼠骨密度及钙、磷含量影响的实验研究。方法采用胃切除术建立大鼠骨质疏松模型共60只,并将其分为5组:胃窦切除术组、胃底切除术组、全胃切除术组、空白对照组和假手术组各12只;术后6个月,应用双能X线吸收法(DEXA)检测大鼠股骨骨密度,应用全自动生化分析仪检测钙、磷等骨代谢生化指标,对结果进行比较。结果与空白对照组比较,胃切除术组大鼠股骨骨密度值显著降低(P<0.05);血清碱性磷酸酶、甲状旁腺激素、血清无机磷均升高(P<0.05);血清总钙、降钙素、骨钙素均降低(P<0.05)。结论胃切除术后能够显著降低大鼠股骨的骨密度和骨矿含量,血清ALP、P升高,肠钙吸收低下,CT分泌减少,BGP分泌减少,PTH分泌亢进的情况下,骨吸收明显增强,这样骨吸收远远大于骨形成,导致骨质疏松的发生。
Objective To explore the effects of Gastrectomy on bone mineral density and calcium and phosphorus in rats.Methods The gastrectomy was used to establish a rat model of osteoporosis.60 rats were divided into five groups and 12 in each group：Antral resection group,Gastric resection group,Total gastrectomy group,Control group,Sham-operated group.After six months,DEXA was adopted to detect rat femur BMD,and Automatic biochemical analyzer was used to detect calcium and phosphorus.Results Compared with control group,gastrectomy（P 〈0.05）;ALP,PTH,P were increased（P〈 0.05）;Ca,CT,BGP were decreased（P 〈0.05）.Conclusion Gastrectomy can significantly reduce femoral BMD and BMC in rats,increase ALP、P,lower intestinal Absorption of calcium and CT,BGP secretion,PTH.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2010年第5期1238-1240,共3页
Lishizhen Medicine and Materia Medica Research
基金
宁夏自然科学基金(No.NZ0895)
