1Martinez LA,Lehrmann H.Isolation of quelling-defective (qde) mutants impaired in posttran-scriptional transgene-in-duced gene silencing in Neurospora crassa[J].Proc Nail Acad Sci USA,1997,94(100):10233.
2Fire A,Xu S,Montgomery MK,et al.Potent and specific ge-netic interferenceby double-strand RNA in eoenorhabditls ele-gans[J].Nature,1998,391(6669):744.
3Chang YC,chou FP,huang HP.et al.Inhibition of cell cy-cle progression by pentaacetyl genipeside in rat c6 glioma cells[J].Toxieol Appl Pharmaeol,2004,198(1):11.
4Jensen NA,pedersen KM,Lihme F.et al.Astroglial C-myc over expression predisposes mice to primary malignant glio-mas[J].J Biol Chem,2003,278(10):8300.
5Wang J,Wang H,Li Z,et al.c-Myc is required for main-tenance of glioma cancer stem cells[J].PLOS One,2008,3(11):3769.
6Masuda TA,Inoue H,Sonoda H,et al.Clinical and biologi-cal significance of S-phase kinase-associate dprotein2(Skp2) gene expression in gastric carcinoma:modulation of malignant phe-notype by Skp2 overexpression,possibly viap27proteolysis[J].Cancer Res,2002,62(13):3819.
7Takanami I.The prognostic value of over expression of skp2 mRNA in non-small cell lung cancer[J].Oncol Rep,2005,13(4):727.
8Gstaiger M,Jordan R,Lim M,et a1.Skp2 is on cogenic and over expressed in human cancers[J].Prec Nail Acad Sci USA,2001,98(9):5043.
9Vonder Lehr N,Johansson S,Wu s,et al.The F box protein Skp2 participates in cMyc proteosomal degradation and acts as a cofactor for C-Myc-regulated transeription[J].Mol Cell,2003,11(5):1189.
1Fire A,Xu S,Montgomery MK,et al.Potent and sepecific genetic interference by doule-stranded RNA in caenorhabditis elegans[J].Nature,1998,391(6669):8063 -8067.
2Tollefsbol TO,Andrews LG.Mechanisms for telomerase gene control in aging cells and tumorigenesis[ J].Med Hypotheses,2001,56(6):630 -637.
3Bernstein E,Caudy AA,Hammond SM,et al.Role for a bidentate ribonuclease in the initiation step of RNA interference[ J ].Nature,2001,409(6818):363 -366.
4Svoboda P,Stein P,Hayashi H,et al.Selective reduction of dormant maternal mRNAs in mouse oocytes by RNA interference[ J].Development,2000,127(19):4147 -4156.
5Brummelkamp TR,Bernards R,Agami R.A system for stable expression of short interfering RNAs in mammalian cells[ J ].Science,2002,296(5567):550-553.
6Pei L, Melmed S. Isolation and characterization of a pituitary tumor-transforming gene (PTTG) [J]. Mol Endocrinol,1997 ;11 (4) :433-41.
7Tfelt-Hansen J, Kanuparthi D, Chattopadhyay N. The emerging role of pituitary tumor transforming gene in tumorigenesis [ J ]. Clin Med Res, 2006;4(2) : 130-7.
8Bradshaw C, Kakar SS. Pituitary tumor transforming gene : an important gene in normal cellular functions and tumorigenesis [ J]. Histol Histopathol,2007 ; 22 ( 2 ) : 219 -26.
9Hunter JA,Skelly RH, Aylwin SJ,et al. The relationship between pituitary tumour transforming gene (FITG) expression and in vitro hormone and vascular endothelial growth factor (VEGF) secretion from human pituitary adenomas [ J ]. Eur J Endocrinol,2003 ; 148 ( 2 ) :203-11.
10Tfelt-Hansen .[, Yano S, Bandyopadhyay S, et al. Expression of pituitary tumor transforming gene (PTrG) and its binding protein in human astrocytes and astrocytoma cells:function and regulation of PTTG in U87 astrocytoma cells [ J]. Endocrinology,2004 ; 145 (9) :4222-31.
