希罗达联合放射治疗对早期食道癌患者疗效观察

Xeloda in combination with radiotherapy in patients with early esophageal cancer

目的:探讨对早期食道癌患者应用希罗达对放射治疗的增敏作用。方法:对131例早期食管癌患者进行希罗达联合放射治疗,并与同期单存放疗患者比较。结果:联合组对患者完全缓解率有影响,能提高患者完全缓解率,联合组总有效率高于单纯放疗组声音嘶哑因为例数太小无法进行比较,患者吞咽困难改善率,联合组优于单纯放疗组,对胸痛影响无差异,且两组治疗患者均未见Ⅲ级以上明显不良反应。结论:联合治疗效果优于单纯放射治疗,希罗达对放射治疗有增敏作用。

Objective To explore the application of Xeloda in patients with early esophageal cancer on the sensitizing effect of radiation therapy.Methods The hospital in January 2007 to December 2009 Radiotherapy of early esophageal cancer were treated 131 patients in Hilo over the same period in combination with radiotherapy and radiotherapy in patients with a single deposit comparison.Results The CR rate in combination group of patients affected,can improve the CR rate in patients,the joint group was more efficient than radiotherapy alone group had a hoarse voice because of the number of cases is too small to compare patients dysphagia improvement rate,the joint group was better than radiotherapy alone group,no difference in the impact of chest pain,and patients treated groups were no apparent toxic effects of grade Ⅲ and above.Conclusion The combination therapy was superior to radiotherapy alone,Xeloda on the radiation sensitizing effect of treatment.