具有药物缓释功能的磷酸钙骨水泥的研究进展

Study on Calcium Phosphate Cement as Drug Delivery System

磷酸钙骨水泥作为一种新型的骨修复材料，以其生物相容性高和易塑形的特点得到了材料界和医学界的广泛关注。利用药物定点缓释，将抗癌或消炎等药物引入磷酸钙骨水泥中，能达到骨修复与冶疗的双重目的。本文综述了具有药物缓释功能的磷酸钙骨水泥的研究进展，包括材料的理化特性和药物缓释机理的研究。研究表明，对不同药物采取合适的包埋技术，并通过调节骨水泥的厚度、药物包埋量等条件可达到药物控制释放的目的。

Calcium phosphate cement(CPC),as a novel biomaterial for repairing bone defects,has proved to be attractive because of its high biocompatibility and self-setting capability.Several recent studies have shown that CPC could also be used as a delivery system for antibiotics and anticancer drugs to provide an efficient solution for the repair and treatment of bone diseases.In this paper,the research of CPC as drug delivery system has been generally introduced in respects of its physicochemical properties and mechanism of drug release.The results suggest that the controlled delivery of drug could be attained by choosing the reasonable implanting operation and adjusting the parameters,such as the thickness of cement,the amount of drug and so on.