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143例广东籍汉族人转化生长因子TGFβ1T869C基因多态性检测 被引量：2

DETECTION OF GENETIC POLYMORPHISM OF TGFβ1T869C IN THE HAN OF GUANGDONG
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摘要 目的了解广东籍汉族人转化生长因子TGFβ1 T869C基因的分布特点。方法应用聚合酶链反应技术对143例广东籍正常人转化生长因子TGFβ1 T869C基因进行扩增,以PstΙ进行限制性内切酶酶切图谱分析,并结合文献进行了不同地区间的分析比较。结果转化生长因子TGFβ1+869 C/C、C/T、T/T表型频率分别为:0.216 8、0.475 5、0.307 8,转化生长因子TGFβ1+869 C、TGFβ1+869T基因频率分别为:0.454 5、0.545 5。结论转化生长因子TGFβ1 T869C基因多态性在不同地区间分布存在着一定的差异。 Objective To identify the distribution feature of TGFβ1 T869C gene in the Hans in Guangdong Province. Meth- ods TGFβ1 T869C genes from normal individuals were amplified with PCR and their restricted enzyme digested maps analysis were done with PstI. Results the gene frequency of TGFβ1T869C was as followed;TGFI3l ＋ 869 C/C,C/T,T/T genotype frequency： O. 216 8,0. 475 5,0. 307 8,TGFβ1 ＋ 869C,TGFβ1＋ 869T Genefrequency：0. 454 5,0. 545 5. Conclusion TGFI31 T869C genes distribution in the Hans in Guangdong Province is different from those in other areas.
作者 孙卫文 车坤兰 陈盛强
机构地区 广州医学院第二附属医院
出处 《现代医院》 2010年第5期19-21,共3页 Modern Hospitals
基金 广东省卫生科技项目(项目编号:A2009270)
关键词 广东籍汉族人 转化生长因子Β1 T869C多态性 Guangdong Han population, TGFB1 T869C, Polymorphism
分类号 R733.702 [医药卫生—肿瘤]
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参考文献9

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共引文献31

同被引文献22

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