摘要
目的:探讨传染性单核细胞增多症(IM)患儿外周血淋巴细胞亚群的变化及意义。方法:采用流式细胞术(FCM)检测IM患儿30例(IM组)更昔洛韦治疗前及治疗1周后外周血淋巴细胞百分比的变化,正常儿童30例作为对照组。结果:IM患儿外周血中CD4+、CD4+/CD8+、CD(16+56)+、CD19+CD23+比健康组均明显下降(P<0.05),CD3+、CD8+比健康对照组明显升高(P<0.05)。更昔洛韦治疗后CD4+、CD4+/CD8+、CD19+ CD23+比初期升高(P<0.05),CD3+、CD8+比初期降低(P<0.05),差异均有统计学意义。结论:EB病毒感染引起机体免疫功能改变是IM发病的关键,更昔洛韦对其有较好疗效。
Objective:To investigate the change of T lymphocyte subjects on peripheral blood mononuclear cell(PBMC) in patients with IM and explore its possible significance.Method:Flow cytometry (FCM) technique was applied to quantitatively analyze T Lymphocyte Subjects in 30 IM patients,and after Ganciclovir Injection treated that is also be analyzed.30 healthy subjects are as the reference group.Result: Relative mean fluorescence intensity (RMFI) of CD4+,CD4+/CD8+,CD(16+56)+,CD19+CD23+ is low in patients with IM in comparison with the controls(P<0.05).But CD3+CD8+ shows reverse variation(P<0.05).After Ganciclovir Injection treated,CD4+,CD4+/CD8+,CD(16+56)+,CD19+CD23+ is more advanced than before(P<0.05),and CD3+CD8+ is lower than before.There are all significance differences.Conclusion:The change of the immune function induced with EB virus is the key point of IM morbidity.The IM patient can obtain good effect with ganciclovir injection treated.
