前列腺癌危险度分级与术后复发关系的研究

The Study Between Prostate Cancer risk Assessment and PSA Recurrence

目的近年来前列腺癌的发病率呈逐年上升趋势．前列腺癌的危险度分级主要用来指导治疗和判断预后。本文通过分析不同危险度前列腺癌根治性手术治疗后生化复发的情况．探讨前列腺癌危险度分级在前列腺癌临床诊治中的应用。方法收集2005年1月至2009年1月在我院泌尿外科由1名固定医生实施前列腺癌根治性手术治疗的患者60例．依据血清PSA、Gleason评分、临床分期将患者分为低、中、高危三组。其中低危组8例、中危组22例、高危组30例。术后随访12个月~60个月，比较低危组、中危组和高危组患者术后生化复发的情况。结果60例前列腺癌患者中低危组、中危组和高危组的生化复发率分别为12．5％、27．27％和56．67％，差别有统计学意义（P〈0．05），低危组和中危组的生化复发率均低于高危组（P〈0．05）。结论前列腺癌患者在行前列腺癌根治性手术治疗后，低危和中危患者的生化复发率均低于高危患者。前列腺癌危险度分级对于治疗和判断预后有指导作用。

Objectives In recent years the incidence of prostate cancer shows an upward trend year by year, and the prostate cancer risk assessment is mainly used to guide treatment and prognosis. This study compares prostate cancer patients＇ PSA recurrent rates in different risk, to evaluate the application of prostate cancer risk assessment in prostate cancer. Methods This study includes 60 men who were treated between Jan. 2005 and Jan. 2009 with radical prostatectomy by one doctor. According to prostate cancer risk assessment these patients are divided into low, intermediate, and high-risk categories. There are 8 patients in low risk category, 22 patients in intermediate risk category and 30 patients in high risk category. These patients have been followed up 12-60 months to compare their PSA recurrent rates. Result The PSA recurrent rate in low risk, intermediate risk and high risk categories are 12.5%, 27.27%, and 56.67% （p〈0.05）. The PSA recurrent rate in low risk and intermediate risk categories are lower than it in high risk category （p〈0.05）. Conclusion The PSA recurrent rate in low and intermediate risk categories are lower than it in high risk category. The prostate cancer risk assessment can be used to guide treatment and prognosis.