依那普利联合螺内酯治疗高血压性心力衰竭临床疗效及安全性分析

Clinical efficacy and safety analysis of enalapril combined with spironolactone in treatment of hypertensive heart failure

目的探讨高血压性心力衰竭的治疗方法,分析依那普利联合螺内酯治疗高血压性心力衰竭的临床疗效及安全性。方法 36例高血压性心脏病所致的心力衰竭患者,在强心、利尿、扩张血管的基础上,用依那普利5～10 mg,每日1～2次,螺内酯20～100 mg,每日2次,联合治疗8周后观察血压和心功能的改善情况。结果全部患者收缩压和舒张压均显著下降(P均<0.01),36例患者经2个疗程治疗后心力衰竭改善显效19例(52.8%),有效15例(41.6%),无效2例(5.6%);临床治疗期间无严重高血钾及其他严重不良反应发生。结论依那普利联合螺内酯治疗高血压性心力衰竭可降低血压、改善心功能和临床症状,降低病死率,是有效和安全的。

Objective To investigate clinical efficacy and safety of enalapril combined with spironolactone in the treatment of hypertensive heart failure. Methods Based on the cardiac, diuretic, dilation of blood vessels, thirty - six patients with heart failure because of hypertensive heart disease, were given enalapril 5 - 10 mg, 1 - 2 times one day, spironolactone 20 -100 mg,2 times one day,combination therapy after 8 weeks, blood pressure and improvement situation of heart function were observed. R^ults Both systolic and diastolic blood pressure of All patients decreased significantly （ all P 〈 0. 01 ）, among 36 patients after two courses markedly after the treatment of heart failure, 19 cases （52.8%） were excellent, 15 cases （41.6%） effective ,2 cases （5.6%）ineffective; no serious hyperkaliemia and other serious adverse reactions happened during the clinical treatment. Conclusion Enalapril combined with spironolactone in treatment of hypertensive heart failure can lower blood pressure, improve cardiac function and clinical symptoms and reduce mortality. It is effective and safe.