水飞蓟宾治疗非酒精性脂肪肝疗效分析

Analysis of silybin in the treatment of non-alcoholic steatohepatitis

目的探讨水飞蓟宾对非酒精性脂肪肝的疗效。方法 50例非酒精性脂肪肝患者随机分成2组:观察组30例,对照组20例。全自动生化分析仪检测治疗前、治疗3个月后肝功能ALT、AST、GGT和血脂TG、LDL-C、HDL-C;B超检查对比治疗前和治疗3个月后肝脏脂肪变程度。结果观察组肝功能血清酶ALT、AST、GGT较治疗前均明显下降(P<0.05),且观察组与对照组疗效比较有显著性差异(P<0.05);在调节血脂方面,2组治疗后TG、LDL-C较治疗前下降(P<0.05),HDL-C较治疗前上升(P<0.05),且观察组疗效更明显(P<0.05)。结论结合控制饮食、降低体质量等措施水飞蓟宾能明显改善非酒精性脂肪肝患者的肝功能、血脂等指标。

Objective To observe the result of silybin in the treatment of non-alcoholic steatohepatitis（NASH）.Methods Fifty patients diagnosed NASH were divided into two groups randomly：30 cases in therapeutic group and 20 cases in control group.AST,ALT,TG,LDL-C,HDL-C of the serum were measured by automatic biochemistry method,efficacy was also valued by B ultrasonic scanning before treatment and 3 months after treatment.Results The ALT,AST,GGT were obviously lower after treatment in therapeutic group than those in control group;After treatment,LDL-C,TG were lower （P0.05）and HDL-C was higher than before in two groups （P0.05）.The efficacy was more obvious in therapeutic group（P0.05）.Conclusion Silybin can significantly prohibit the progression of nonalcoholic fatty liver disease with combined control diet,weight reduction and so on.