原发性闭角型青光眼房水循环系统动态建模与仿真

Modeling and Simulation for the Dynamic System of the Primary Angle-closure Glaucoma

原发性闭角型青光眼是我国最常见的不可逆性致盲眼病,由于其发病机制极其复杂,诊断和治疗手段主观且有限,对其进行建模与仿真有重要的医学意义.在前期对人眼房水动力学系统仿真建模的研究基础上,结合闭角型青光眼的病理学特点及临床数据,提出了适用于原发性闭角型青光眼人眼房水循环系统的动力学仿真模型,并运用数字仿真的方法对模型进行了仿真运行,获得了与临床结论较为一致的结果,能较好地模拟原发性闭角型青光眼病理状态下的房水运行机制.

It is acknowledged that the primary angle-closure glaucoma（PACG） characterized by irreversible vision loss,is the most widespread kind of eye disease.As the complicated pathological mechanism and the limited diagnosis and therapeutic tool of PACG,the researches on the field of modeling and simulation for the dynamic system of PACG have great medicinal significance.Based on our previous work on some simulation experiments of aqueous humor flow on normal eyes coincide with the pathological characteristics and clinical parameters of PACG,a dynamic simulation model was built for the system of aqueous humor flow on PACG.This model has been digitally simulated for the mechanism of aqueous humor flow of PACG,the results were consistent with clinical observations,and give the gist of aqueous humor flow of PACG.