灰黄霉素的研究进展

Research Advances of Griseofulvin

灰黄霉素(Griseofulvin)是从灰黄青霉(Penicillium griseofulvin)培养液中得到的一种含氯代谢产物,是一种非多烯类的抗真菌抗生素.我国目前投产的灰黄霉素产生菌的发酵单位已达世界领先水平,而且使用原料简单,产品成本低,在国际市场上有很强的竟争力.概述了灰黄霉素的研究与应用进展,包括通过耐前体变株的筛选可获得灰黄霉素高产株;培养基中氯化物无机盐对该化合物的代谢有较重要的影响;采用超声波技术进行提取可缩短提取时间,提高提取率;由于灰黄霉素的溶解度很低,可对灰黄霉素的超细化处理做成喷雾剂或缓释药物.灰黄霉素不仅是一种普遍应用于临床治疗皮肤和角质层真菌感染的抗生素,而且在农业植物保护方面有着良好的应用前景.

Griseofulvin is a chlorine-containing metabolite obtained from culture liquid of Penicillium griseofulvin.It is a non-polyenes antifungal antibiotic.The fermentation unit of griseofulvin producing strain in China has reached the world advanced level with advantages of simple raw material and low cost,which leads to a strong competitiveness in international market.This paper reviews the research and application advances of griseofulvin,including how to obtain high-producing strain by screening the resistant precursor mutant,the important effect of chlorid inorganic salts in cultural medium on its metabolize,using ultrasonic technique to shorten the extraction time and enhance the extraction ratio.Also,superparticle treatment can be used in produce of griseofulvin to make spray and controlled release drugs due to its low solubility.Griseofulvin is not only an antibiotic being wildly used in the clinic treatment of fungal infections on skin and cuticle,but also having great application potent in the area of agricultural plant-protection.