气相色谱保留值与疏水亲脂参数的关系

A Study on Relationship Between Gas Chromatogra- phic Retention Values and [Hydrophobia Parameters

本文利用数理统计方法,研究了分子结构参数与气相色谱保留行为的关系,重点考察了疏水亲脂参数IogP以及结合诱导效应指数F和分子连通性指数~1X,对于极性和非极性物质色谱保留值的不同贡献。并通过对保留值的预测,证明了它们的密切相关性。

Ghose's atomic hydropliobic parameters are used to correlate with gas chromatographi c retention values as well as molecular connectivity 'x and induced effect index,F.Correlation equations with these three parameters for alkanes,aliphatic alcohols,aldehydes,acids and amines are given The results indicate that hydrophobic,parameters are good parameters to represent the non-polar interactions between solute and stationary phase and thus are useful in correlation with gas chromatographic retention values.