白细胞增多的不同疾病患者NAP积分的检测与意义

Correlation of neutrophil phosphatase alkaline activity and leukocytosis

目的探讨白细胞增高的疾病患者的中性粒细胞碱性磷酸酶(NAP)积分的变化及其临床意义。方法采用Kaplow偶氮偶联法对140例外周白细胞增高患者的EDTA抗凝血,其中包括32例感染性疾病患者、34例手术后患者、25例肿瘤患者(使用集落刺激因子后)、24例妊娠妇女以及25例危重患者,对他们进行中性粒细胞碱性磷酸酶染色,并显微镜镜检计算其积分。另外,选择25例健康体检者作为对照组。结果中性粒细胞碱性磷酸酶染色在感染性疾病患者、手术后患者、肿瘤患者、妊娠妇女积分均高于正常,而在危重患者积分却低于正常。结论在不同疾病患者中性粒细胞碱性磷酸酶积分是不同的,可以将其作为病情观察及疗效的判断指标。

Objective To study the corralation of neutrophil alkaline phosphatase activity and the disease with leukocytosis.Methods NAP score was estimated using the Kaplow method,and we studied its activity in different groups of diseases with leukocytosis,including 32 cases of infection,34 cases of post-operation,25 cases of tumor,24 cases of gestation women and 25 cases with critical diseases.Another 25 healthy subjects are chosen as controls.Results Increased NAP scores were found in the groups of infections,postoperative,tumors and gestation women,respectively,while decreased NAP activity was demonstrated in the group of critical diseases.Conclusion NAP activity is correlated with the diseases with leukocytosis and the NAP score is significant parameter in assessing clinical diseases.