围绝经期性激素水平与抑郁症状的相关分析

Correlation analysis between sexual hormone levels of perimenopausal women and their depressive symptoms

目的 探讨围绝经期妇女性激素水平与抑郁症状的相关性.方法 收集2008年10月～2009年3月就诊于东南大学附属中大医院妇科门诊的104名40～58岁确诊为围绝经期的妇女,采用一般情况问卷和抑郁自评量表（SDS）进行调查并加以分析.结果 104例符合入选标准的围绝经期妇女,其血清卵泡刺激素、黄体生成素、雌二醇水平与抑郁指数的相关系数分别为-0.071、0.062、-0.048,均P〉0.05,均无显著的相关性;而血清孕酮水平与抑郁指数的相关系数为-0.264,P〈0.05,呈显著负相关;血清睾酮水平与抑郁指数的相关系数为0.277,P〈0.05,呈显著正相关.结论 围绝经期随着卵巢功能的衰退,血清中孕酮水平的下降和睾酮的水平逐渐升高可能是导致围绝经期抑郁症发病率升高的重要因素.

Objective To investigate correlations of sexual hormone levels of perimenopausal women with their depressive symptoms. Methods 104 women aged 40 - 58 years who visited to the Gynecological Clinic of The Affiliated Zhongda Hospital of Southeast University in a period from October, 2008 to March, 2009 who were regarded as perimenopausal women were selected in the study and were investigated with general questionnaire and self-rating depression scale （SDS）. Results The correlation coefficients of serum levels of follicle stimulating hormone（ FSH）, luteinizing hormone（ LH）, estradiol（ E2 ） of 104 perimenopausal women who met the inclusion criteria and their depression index were - 0. 071, 0. 062, - 0. 048 respectively, all P 〉 0.05, showing no significant correlation. While the correlation coefficient between serum progesterone（P） level of the perimenopausal women and their depression index was -0. 264, P 〈 0.05, and showed a significant negative correlation. The correlation coefficient between serum testerone（T） level of the perimenopausal women and their depression index was 0.277, P 〈 0.05, and showed a significant positive correlation. Conclusion With decline of ovarian function in perimenopausal period, serum level of P of the women descends and serum level of T gradually increases, which may be the important cause of increased incidence rate of perimenopausal depression.