利伐沙班对原位肝移植大鼠血液流变学的影响

Effect of rivaroxaban on hemorheology in rats undergoing orthotopic liver transplantation

目的探讨利发沙班对肝移植大鼠血栓形成的预防作用。方法成年大鼠40只,随机分为A、B、C、D四组,均开腹行原位肝移植。于术前1d、手术中、术后1、2、3d,A组分别口服利伐沙班1次,剂量为5mg/kg,B组分别静脉输注低分子右旋糖酐20ml,C组分别皮下注射低分子肝素200U/kg,D组为空白对照组,只作肝移植,不用抗凝药物。术前、术后2h和术后3d检测血液流变学。结果与D组比较,A、B、C组大鼠肝移植前后血液流变学均有明显改善。A、B、C三组血液流变学指标差异无统计学意义。D组有1只大鼠死亡。结论利伐沙班能有效预防大鼠肝移植术后血液的高凝状态。

Objective To study the efficiency of rivaroxaban in preventing thrombosis in rats undergoing orthotopic liver transplantation（OLT）. Methods Fourty rats were randomly divided into 4 groups with 10 rats each and underwent OLT. On the day before operation, during operation, and on the 1st , 2nd, and 3rd postoperative day, the rats in group A were given oral rivaroxaban 5 mg/kg daily, those in group B intravenous infusion of low molecular weight dextran 5 ml, those in group C abdominal cavity injection of LMWH 200μg/kg, and those in group D no drug as the controls. Blood samples were taken for hemorheological examinations before operation, at 2 h and on the 3rd day after operation. Results Compared to group D, the hemorheological criteria were significantly improved in groups of A, B and C （P〈0.05）. There were no significant differences in hemorheological criteria among groups of A, B and C. One rat in group D died. Conclusion Rivaroxaban can effectively prevent hypereoagulative state in rats after OLT.