特异性免疫治疗对鼻息肉手术预后干预作用研究

Research on SIT's intervention in NPs after FESS

目的:探讨特异性免疫治疗(SIT)对鼻息肉伴常年性变应性鼻炎患者行功能性鼻窦内镜手术(FESS)的预后干预作用。方法:采用随机分组方法将确诊为鼻息肉伴常年性变应性鼻炎的患者随机分成2组,Ⅰ组:FESS+术后SIT组;Ⅱ组:FESS组。分别对2组患者进行术前、术后1年、术后2年症状及体征评分并进行对比,采用鼻腔鼻窦结局测量20条(SNOT-20),鼻内镜(Lund-Kennedy)评分法及CT(Lund-Mackay)评分法。结果:2组患者术后1年及2年SNOT-20量表的20个条目总分与5大条目总分、鼻内镜评分、CT评分指标均有明显好转(P<0.05),但2组间存在显著性差异,Ⅰ组疗效优与Ⅱ组。结论:SIT可减少鼻息肉术后复发,改善预后。

Objective：To investigate specific immunologic therapy（SIT）intervention in patients with nasal polyps accompanied with perennial rhinitis after functional endoscopic sinus surgery（FESS）.Method：To divide patients with nasal polyps into two groups randomly：group Ⅰ：FESS＋SIT after operation;group Ⅱ：FESS only. To compare the symptom and physical sign of the 2 groups before the operation and 1 and 2 years after the operation, with SNOT-20 and Lund-Kennedy and Lund-Mackay Standard.Result：Both of the 2 groups＇ final scores of the total 20 items and the most important 5 items of SNOT-20 and Lund-Kennedy and Lund-Mackay were greatly improved, however there is an obvious difference between them： the therapeutic effect of groups Ⅰ is better than group Ⅱ.Conclusion：SIT can reduce the recurrence of nasal polyps after operation, and improve the state after treatment.