芍药甘草汤提取物(芍甘多苷)对实验性肝损伤的影响

Influence on experimental liver injury of extraction from Peony and Licorice Decoction

目的:探讨芍甘多苷(DSM)对多种实验性肝损伤的保护作用。方法:分别采用四氯化碳(CCl4)、D-氨基半乳糖(D-GalN)诱发小鼠化学性急性肝损伤,内毒素+卡介苗(LPS+BCG)诱发小鼠免疫性肝损伤,然后灌胃给予不同剂量的DSM,每天1次,连续4天,观察药物对血清转氨酶和肝脏病理形态的影响。结果:模型组小鼠血清转氨酶及肝脏病理组织学评分明显增高,DSM组血清转氨酶,肝脏病理组织学评分有不同程度的降低。结论:DSM能减轻化学性和免疫性肝损伤,具有明显的保肝作用。

Objective：To investigate protective effect of shaogan polyglycosides on murine experimental liver injury. Methods：Mices with acute liver injury induced by CCl4 and D-GalN,with immunological liver injury induced by LPS＋BCG are given different doses of shaogan polyglycosides（DSM）,then observation serum transaminases and pathologic morphology of liver. Results：DSM can reduce serum transaminases and improve pathological changes of mices with all kinds of liver injury. Conclusions：DSM can alleviate chemical and immunological liver injury ,has obvious liver protection effect.