摘要
目的探讨雌激素受体(ER)和孕激素受体(PR)在甲状腺乳头状癌中的表达,以及ER、PR与肿瘤生物学特征的关系。方法取新鲜甲状腺乳头状癌标本69例,结节性甲状腺肿7例,用免疫组织化学方法检测ER、PR的表达。分析受体与肿瘤生物学特征的关系。结果在甲状腺乳头状癌中,ER和PR的表达率分别为52.17%和46.38%,结节性甲状腺肿没有ER和PR表达,ER和PR的表达与患者性别、肿瘤大小以及MACIS评分无关,但是PR与肿瘤浸润甲状腺包膜以及淋巴结转移成正相关(P<0.05),ER与患者年龄成负相关。结论甲状腺乳头状癌中ER、PR的表达高于结节性甲状腺肿,甲状腺乳头状癌中PR的表达反映肿瘤浸润甲状腺包膜和淋巴结转移情况,ER表达随着患者年龄增加而减少。
Objective To determine the expression of ER and PR in human papillary thyroid carcinoma（PTC）,and to explore their correlation with the clinical features of thyroid carcinoma.MethodsTaking 69 samples of fresh papillary thyroid carcinoma（PTC） and 7 samples of nodular goiter from surgery,the expression of ER and PR was detected in human papillary thyroid carcinoma by immunohistochemistry.And the correlation of the expression of ER / PR and the biological characteristics of tumor was analyzed.Results In PTC samples,ER and PR immunoreactivity were detected for 52.17% and 46.38%,respectively.No ER nor PR expressed in nodular goiter.The expression of ER and PR was not related with sex,tumor size and tumor grade malignancy,but the expression of PR was positively correlated with capsular invasion and lymph nodes metastasis（P〈0.05）,the expression of ER was negatively correlated with age.Conclusion The expression of ER and PR was higher in PTC than nodular goiter.The expression of PR in PTC may be a sign of capsular invasion and lymph nodes metastasis,the expression of ER decreased as the patients grew older.
出处
《基础医学与临床》
CSCD
北大核心
2010年第6期635-639,共5页
Basic and Clinical Medicine
