膈肌生物反馈训练联合抑酸治疗胃食管反流相关性咳嗽患者疗效的初步观察

Effect of diaphragm biofeedback training combined with proton pump inhibitor in the treatment of gastroesophageal reflux related cough

目的观察膈肌生物反馈训练(DBT)联合质子泵抑制剂(PPI)治疗胃食管反流(GER)相关性咳嗽的效果。方法 11例GER相关性咳嗽患者,填写问卷后学习DBT方法 ,同时服用PPI(雷贝拉唑10 mg,每日2次),每2周随访1次,第8周末完成健康相关生活质量调查表(SF-36),第12周末接受电话随访。结果 DBT联合PPI治疗后2周,反流症状总评分(TRSS)和咳嗽评分(SC)改善均>50%;治疗8周,疗效稳定,生活质量中生理职能、活力、精神健康、社会功能、躯体疼痛及总体健康这6个维度的评分显著提高(P<0.05)。第12周末随访,PPI减量后患者症状稳定。结论 DBT联合PPI治疗GER相关性咳嗽,能在短期内改善患者症状及生活质量,提供了新的治疗途径。

Objective To observe the effect of diaphragm biofeedback training（DBT） combined with proton pump inhibitor（PPI） to treat gastroesophageal reflux（GER） related cough.Methods Totally 11 patients with GER related cough were investigated.After completing questionnaire,they were taught how to practice DBT daily in home and record diary,meanwhile taking PPI（Rabeprazole 10 mg,twice daily）.Follow-up was carried out every 2 weeks and asked them to complete health-related quality of life questionnaire（SF-36） at the end of the 8th week,and call them at the end of the 12th week.Results Total reflux symptom score（TRSS） and score of cough（SC） reduced by 50% after treatment of DBT combined with PPI.Symptoms remained for 8 weeks,and score of role limitations due to physical health,vitality,mental health,social functioning,body pain,general health increased significantly（P〈0.05）.At the end of the 12th week,symptoms remained stable while dosage of PPI decreased.Conclusion DBT combined with PPI can significantly improve patients＇ symptoms and quality of life in a short term,which brings forward a new therapeutic approach for patients of GER related cough.