布地奈德吸入治疗时间对特应性毛细支气管炎婴幼儿后喘息的影响

Analysis of the relationship between time of inhaled budesonide treatmend and wheezing effect in infant with atopic bronchiolitis

目的探讨特应性毛细支气管炎婴幼儿使用布地奈德吸入治疗对喘息的影响。方法选择2006年1月～2007年3月就诊于襄樊市一医院儿科的83例特应性毛细支气管炎患儿,入院后均查外周血嗜酸性粒细胞、血清总IgE、血TH1/TH2水平,应用布地奈德吸入治疗,按应用布地奈德治疗的疗程随机分为1周组、3个月期组和1年期组,1周组仅在急性期用药1周,3个月组和1年组在急性期与1周组用药相同,急性期后继续予布地奈德吸入治疗。观察治疗后2年内患儿的复发情况。结果经治疗后2年内1周组复发23例占67.65%,3个月期组复发6例占22.22%,1年期组复发2例占9.09%。组间比较差异具有显著性(P<0.001)。结论对特应性毛细支气管炎患儿,应早期使用糖皮质激素吸入治疗,疗效明显,可有效减少喘息的复发,但吸入激素持续时间并不能减少停药后2年内喘息的发生。

Objective To investigate the relationship between the course of treatment of inhaling budesonide and wheezing effect in infant with atopic bronchiolitis.Methods A total of 83 children with atopic bronchiolitis were treated by budesonide inhalation.All of them were divided randomly into one-week group,three-month group and the one-year group according to the course of the treatment.All groups were taken the same treatment during the acute period in the first week.The three-month group and the one-year-group were continued inhaling budesonide treatment after the acute period.Then we observed the recurrence of infant with atopic bronchiolitis in two years.Results Twenty-three patients in the one-week group recurred（67.65%）in two years.Six patients in the three-month group recurred （22.22%）.Two patients in the one-year group recurred （9.09%）.Conclusion The infant with atopic bronchiolitis should be treated by inhaled glucocorticoid treatment more early and the treatment could reduce recurrence rate.Time of inhaled budesonide can not decrease the risk of wheezing after bronchiolitis.