抗结核治疗中药物热48例诊治体会

Diagnosis and treatment of 48 cases of drug fever during antituberculosis therapy

目的探讨抗结核药物所致的药物热的品种、发生率及症状,提高对药物热的认识。增强药物热和其他原因引起的发热的鉴别意识。方法回顾总结抗结核治疗中药物热48例,观察导致药物热的品种,发生的时间,伴随的症状及解决的方法。结果抗结核药物发生药物热的频率较高,尤以利福平、对氨基水杨酸钠、链霉素最常见。结论结核病治疗过程中需要关注抗结核药物发生药物热的可能性,尤其是出现反常发热及嗜酸性粒细胞升高时,及时停药是治疗的关键。

Objective To explore the drug varieties,frequency and symptoms of the drug fever caused by antituberculosis therapy,to improve the understanding of drug fever and to raise the sense of differential diagnosis on drug fever and the fever caused by other causes.Methods 48 cases of drug fever in the anti-TB treatment were retrospectively summed up,and the drug varieties which could cause drug fever,the time it happened,the symptoms and the solving method were observed.Results Because of the over-protracted use and so many varieties,drug fever happened frequently,especially Rifapicin,Para-aminosalicylate and streptomycin.Conclusion Drug fever caused by antituberculosis therapy happens frequently.We should pay special attention when used with other antibiotics.