用心率变异性谱分析法研究振动性白指患者自主神经系统对冷刺激的反应(英文)

Autonomic Nervous Response to Cold Provocation in Vibration Induced White Finger(VWF) Patients with HRV Analysis

目的研究振动性白指患者的自主神经系统对冷刺激的反应。方法２２名振动性白指患者（ＶＷＦ组）及１９名正常对照（对照组）进行了局部冷水刺激实验，记录受试者的心电信号，实验后将记录的心电信号通过处理转化为ＲＲ间期信号，然后对这些ＲＲ间期信号进行功率谱分析，计算标准化的ＬＦ（０．０２～０．１５Ｈｚ）功量（ＬＦ％），标准化的ＨＦ（０．１５～０．４０Ｈｚ）功量（ＨＦ％），以及ＬＦ／ＨＦ比率。结果冷暴露开始后，ＶＷＦ组及对照组的ＨＦ％与暴露前的水平相比都有显著下降，ＶＷＦ组的ＬＦ／ＨＦ比率与暴露前的水平相比有显著增大，而且冷暴露中ＶＷＦ组的ＬＦ／ＨＦ比率显著高于对照组的相应的ＬＦ／ＨＦ比率。结论冷刺激导致ＶＷＦ组和对照组的副交感神经活动减弱，但对照组还能保持交感与副交感的平衡，而ＶＷＦ组却不能保持两者平衡，交感神经活动明显占优，冷刺激中ＶＷＦ组ＬＦ／ＨＦ比率明显高于对照组的ＬＦ／ＨＦ比率说明振动性白指患者的交感神经系统对冷刺激可能存在过敏反应。

Objective To evaluate the autonomic nervous response of Vibration induced white finger(VWF) patients to cold provocation test by power spectral analysis of heart rate variability(HRV). Methods The cold provocation test was conducted in 22 VWF patients and 19 healthy volunteers.ECG was recorded during the experiment,and converted to R R interval signals after the experiment.The normalized LF[(0.02～0.15) Hz] component power, normalized HF[(0.15～0.40) Hz] component power and the ratio of LF to HF power(LF/HF ratio) were calculated. Results At the beginning of cold exposure,there were a significant decrease of HF% in both groups,and a significant increase of LF/HF ratio in VWF group as compared with pre exposure value. The LF/HF ratio in VWF group during cold exposure was significantly higher than that in the control group. Conclusion Cold stimuli induced depression of parasympathetic nervous system in both groups, and the sympatho-vagal balance was maintained in the control group,but in VWF group it became sympathetic dominance during cold exposure. The sympathetic nervous system of VWF patients may be hyperreactive to cold stimuli.