焦虑情绪大鼠血脂水平分析

Analysis of Serum lipid level in rats with anxiety

目的分析焦虑情绪大鼠血脂水平,探讨焦虑情绪可能诱发冠心病的关键作用途径。方法选取健康Wistar大鼠60只,随机分为正常对照组、高脂血症组、焦虑情绪组、焦虑合并高脂血症组,除对照组外,分别予脂肪乳剂灌胃、空瓶给水应激建立高脂血症、焦虑情绪、焦虑合并高脂血症模型,观察4组大鼠血脂差异。结果高脂血症组TCH、TG、LDL-C水平较正常对照组、焦虑情绪组差异有统计学意义,焦虑合并高脂血症组TCH、LDL-C水平升高较其他3组均差异有统计学意义,单纯焦虑组TG、LDL-C水平较正常对照组差异有统计学意义。结论焦虑情绪可能通过影响大鼠脂质代谢,诱发冠状动脉粥样硬化。

Objective To analyze serum lipid concentrations in rats and explore the＇role of the anxiety in patho- genesis of coronary heart disease. Methods Sixty healthy Wistar rats were randomly assigned into 4 groups ： normal con- trol group （ NC ）, high - fat control group （ HFC ）, anxiety high - fat group （AHF） and anxiety control group （ AC ）. Hy- perlipemia and anxiety models were constructed using fat emulsion lavaging and empty water bottles stress, respectively, Serum TC, TG, LDL - C and HDL - C in rats were detected. Results The TCH, TG, LDL - C of HFC concentrations in HF were significantly higher than those in NC and AC, while TCH and LDL - C of AHFC in AHF were significantly higher than those in the other 3 groups. There were significant differences of TG and LDL - C between AC and NC. Con- clusion Anxiety may affect lipid metabolism and induce coronary atherosclerosis.