灯盏细辛与尼莫地平治疗血管性抑郁症的疗效比较

Control trial of dengzhanxixin and nimodipine in vascular depression treatment

目的探讨灯盏细辛与尼莫地平治疗血管性抑郁症的临床疗效。方法应用汉密尔顿抑郁量表(HAMD)和简易智能精神状态检查量表(MMSE)分析评估血管性抑郁症患者,分别采用灯盏细辛注射液联合氟西汀、尼莫地平联合氟西汀、单纯氟西汀对患者分组治疗。结果 3组患者治疗前后HAMD总分均差异有显著性(P<0.01),3组之间比较:灯盏细辛组疗效优于尼莫地平组及氟西汀组(P<0.01,P<0.05)。灯盏细辛组与尼莫地平组患者认知功能均有明显改善(P<0.01),两组之间差异无显著性(P>0.05)。结论灯盏细辛联合氟西汀治疗血管性抑郁的疗效优于尼莫地平联合氟西汀,患者认知功能障碍的改善两组疗效相近。

Objective To investigated the efficacy of Dengzhanxixin and Nimodipine in treating vascular depres- sion. Methods 104 patients with vascular depression were included and randomly assigned into 3 groups ： Dengzhanxix- in injection with Fluoxetine group, Nimodipine with Fluoxetine group and Fluoxetine group. The mental status was as- sessed with Hamilton depression scale （HAMD） and Mini mental state examination （MMSE）. Results There were sig- nificant improvements of HAMD total scores in all 3 groups after treatment （P 〈0. 01 ）. The curative effect had significant difference between Dengzhanxixin injection and Nimodipine group （P 〈0.01 ）. There was significant improvement in cog- nitive function in both groups （P 〈 0. 01 ）, but no significant difference revealed between the two grops （P 〉 O. 05 ）. Con- elusion Dengzhanxixin injection is more effective than Nimodipine in treating vascular despression. Two medicines show equal efficacy in cognitive function improvement.