维生素E-β-环糊精包合物溶出度研究及Weibull模型分析

Dissolution Property of Vitamin E-β-cyclodextrin Inclusion Compound Determined by UV and Analyzed by Weibull's Model

目的:制备维生素E-β-环糊精包合物,进行包合物的溶出度考察及Weibull模型分析。方法:采用紫外分光光度法测定维生素E-β-环糊精包合物含量及溶出度,利用Excel电子表格软件分别计算维生素E-β-环糊精包合物和物理混合物的Weibull分布参数。结果:制成的维生素E-β-环糊精包合物能显著提高维生素E的体外溶出度,溶出过程符合Weibull分布模型,溶出参数r、m、β、Td有统计学差异(P<0.05)。结论:β-CYD能增加难溶性药物维生素E在水中的溶解性,有望提高药物的生物利用度。

Objective：Preparation of vitamin E-β-cyclodextrin（VE-β-CYD） inclusion compound,the inclusion compound and physical mixture preliminary dissolution.Methods：To establish a UV method for the determination of VE in VE-β-CYD and the dissolution of the VE-β-CYD.,Data were analyzed by Weibull＇s distribution model.Results：The dissolution rate in vitro of VE-β-CYD were obviously raised.There is still some diference in their dissolution parameters r、m、β、Td（P〈0.05）.Conclusion：β-CYD could help to improve the water-solubility of the insoluble drugs,it might be improve bioavailability of drugs.