摘要
目的:研究癫痫"从肝论治"、"从痰论治"的复方柴胡疏肝汤及定痫丸对戊四氮(PTZ)慢性点燃大鼠痫性发作的影响。方法:建立大鼠PTZ慢性点燃的癫痫模型,选取完全点燃大鼠随机分为4组,即生理盐水组(A组)、丙戊酸钠组(B组)、定痫丸组(C组)、柴胡疏肝汤组(D组),连续灌胃给药28天,于给药第7、14、21及28天观察大鼠阵发性痉挛发作潜伏期、痫性发作级别以及强直性惊厥发生率。结果:C组与D组在各用药时间点均能不同程度延长PTZ慢性点燃大鼠的阵发性痉挛发作潜伏期,与A组相比有显著性差异(P<0.05或P<0.01),与B组作用相当(P>0.05),而C组与D组无显著性差异(P>0.05)。结论:癫痫"从肝论治"的复方柴胡疏肝汤、"从痰论治"的复方定痫丸均能明显抑制PTZ致痫大鼠的痫性发作,有明显的抗癫痫作用,但两复方在时效关系中可能存在差异。
Objective:To explore the effect of Chaihu Shugan Tang(CHSGT,"from the Liver") and DingXianWan(DXW,"from the sputum ") on epileptic seizure of rats induced by pentetrazole(PTZ).Methods:To establish the model of chronic kindling rats induced by pentylenetet.Fully kindled rats were randomly divided into six groups :NS group(group A),VPA group(group B),DXW group(group C),CHSGT group(group D),During the intragastirc administration for 28 days,the seizures of epileptic rats were observed on the 7th,the 14th,the 21th and the 28th day.Results:Group C and group D prolongde the seizure potential period significantly comparing with group A(P〈0.05),and comparing with group B there was no difference(P〉0.05).While there was no obvious difference between group C and group D(〉P0.05).Conclusion:Chaihu Shugan Tang("from the Liver")and DingXianWan("from the sputum ") can both inhibit the epileptic seizure of epileptic rats induced by PTZ obviously;both have prominent antiepileptic effect.But there maybe some difference in the relationship of their effect to their action time between Chaihu Shugan Tang and DingXianWan.
出处
《数理医药学杂志》
2010年第3期347-350,共4页
Journal of Mathematical Medicine
基金
国家中医药管理局中医药科学技术研究专项(06-07JP34)
2007年广东自然基金课题(07002548)
广东省中医药局科研课题(2007116)
广东省科技计划课题(2007B080701015)
2008年广东省科技计划课题(2008B080701028)
关键词
癫痫
同病异治
柴胡疏肝汤
定痫丸
PTZ
痫性发作
epilepsy
heterotherapyforhomopathyj chaihushugantang
dingxianwan
pentylenetetrazol
epileptic seizure