期刊文献+

浅谈生理药动学模型及其在兽药残留研究中的应用 被引量:2

下载PDF
导出
摘要 药动学是应用动力学原理研究药物在体内的吸收、分布、生物转化(代谢)和排泄过程的速度规律的一门科学。在药动学研究中,经常采用数学模型来模拟药物在体内的速率过程,其中应用最多的是房室模型。房室模型就是按照机体对药物的不同处置速度,把机体分为抽象的“一室”、“二室”或“多室”。
作者 杨帆
出处 《广东畜牧兽医科技》 2010年第3期3-5,共3页 Guangdong Journal of Animal and Veterinary Science
  • 相关文献

参考文献7

  • 1罗松柏,何绍雄.生理药代动力学模型的进展与应用[J].药学学报,1997,32(2):151-160. 被引量:10
  • 2Wada D R, Stanski D R, Smith G, et al.A PC-based graphical simulator for physiological pharmacokinetic models[J].Computer Methods and Programs in Biomedicine, 1995:245-255.
  • 3Brocklebank J R, Namdari R. An oxytetracycline residue depletion study to assess the physiologically based pharmokinetic(PBPK)model in farmed Atlantic salmon [J].Canadian Veterinary Journal, 1997,38:645-646:.
  • 4Law F.A physiologically based pharmacokinetic model for predicting the withdrawal period of oxytetracycline in cultured Chinook salmon(Onchorhynchus tshawytscha)[M].1999.105-121.
  • 5Craigmill A L.A physiologically based pharmacokinetic model for oxytetracycline residues in sheep [J].Journal of veterinary pharmacology and therapeutics, 2003,26(1):55-63.
  • 6Buur J L, Bayes R L, Craigmill A L, et al. Development of a physiologic-based pharmacokinetic model for estimating sulfamethazine concentration in swine and application to prediction of violative residues in edible tissues[J].American Journal of Veterinary Research, 2005,66(1):1686-1693.
  • 7Buur J, Baynes R, Smith G, et at. Use of Probabilistic Modeling within a Physiologically Based Pharmacokinetic Model To Predict Sulfamethazine Residue Withdrawal Times in Edible Tissues in Swine[J].Antimicrobial agents and chemotherapy, 2006,50(7):2344-2351.

二级参考文献1

  • 1Dong M H,Comput Methods Progr Biomed,1994年,45卷,213页

共引文献9

同被引文献32

  • 1黄亮,蒋学华,张勤,兰轲.生理药动学模型研究利多卡因静脉给药的体内过程[J].中国药学杂志,2006,41(8):585-589. 被引量:13
  • 2Etienne M,Jemmali M.Effects of zearalenone(F2)on estrous activity and reproduction in gilts[J].J Anim Sci.1982,55(1):1-10.
  • 3Upton R N.Organ weights and blood flows of sheep and pig forphysiological pharmacokinetic modelling[J].J Pharmacol ToxicolMethods.2008,58(3):198-205.
  • 4Shin B S,Hong S H,Bulitta J B,et al.Physiologically basedpharmacokinetics of zearalenone[J].J Toxicol Environ Health A.2009,72(21-22):1395-1405.
  • 5Biehl M L,Prelusky D B,Koritz G D,et al.Biliary excretionand enterohepatic cycling of zearalenone in immature pigs[J].Toxicol Appl Pharmacol.1993,121(1):152-159.
  • 6Kuiper-Goodman T,Scott P M,Watanabe H.Risk assessment ofthe mycotoxin zearalenone[J].Regul Toxicol Pharmacol,1987,7(3):253-306.
  • 7Zinedine A,Soriano J M,Molto J C,et al.Review on the toxicityoccurrence metabolism detoxification regulations and intake of zearalenone:an oestrogenic mycotoxin[J].Food Chem Toxicol,2007,45(1):1-18.
  • 8Yang F,Sun N,Sun Y X,et al.A physiologically based pharmacokinetics model for florfenicol in crucian carp and oral-to-intramuscular extrapolation[J].J Vet Pharmacol Ther.2013,36(2):192-200.
  • 9Ramos A J,Hernandez E,Pladelfina J M,et al.Intestinal absorption of zearalenone and in vitro study of non-nutritive sorbentmaterials[J].International Journal Of Pharmaceutics,1996,128(1-2):129-137.
  • 10Danicke S,Swiech E,Buraczewska L,et al.Kinetics and metab?olism of zearalenone in young female pigs[J].J Anim Physiol Anim Nutr(Berl),2005,89(7-8):268-276.

引证文献2

二级引证文献4

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部