纳洛酮联合丹参对新生儿缺氧缺血性脑病血管活性物质的影响

Effect of Naloxone Combined with Radix Salviae Miltiorrhiae on Vasoactive Substance in Neonatus with Hypoxie-ischemic Encephalopathy

目的:观察纳洛酮联合丹参对新生儿缺氧缺血性脑病(HIE)患儿血管活性物质一氧化氮(NO)及血栓烷B2(TXB2)含量的影响。方法:观察组32例HIE患儿给予纳洛酮联合丹参注射液治疗,对照组30例患儿单纯给予纳洛酮;分别检测治疗前后的NO及TXB2水平并测取同期30例健康新生儿NO及TXB2作为参考值。结果:健康新生儿的NO水平为(62.5±14.7)μmol/L,TXB2水平为(61.7±19.4)ng/L;治疗前62例HIE患儿NO及TXB2分别显著低于和高于以上水平(分别为P=0.015,P=0.022)。治疗后观察组NO水平回升至与参考值无统计学差异,且显著高于对照组(P=0.024);治疗后观察组的TXB2水平下降至与参考值无统计学差异,且显著低于对照组(P=0.021)。相关性分析显示治疗后NO与TXB2呈较强非负相关性(相关系数r=-0.881,P=0.001)。结论:在使用纳洛酮的基础上加用丹参可更有效的升高血管舒张因子NO并降低血管收缩因子TXB2含量。

Objective：To explore the effect of naloxone combined with Radix Salviae Miltiorrhiae（RS）on the vasoactive substance（VAS）：nitrogen monoxidum（NO）and thromboxane B2（TXB2）,and analyze their correlation for neonatus with hypoxie-ischemic encephalopathy（HIE）.Methods：Based on routine treatment,30 neonatus in the control group were given naloxone injection,and the other 32 neonatus in the observation group were given naloxone combined with RS injection.The serum NO and TXB2 of the two groups were compared before and after treatment and another 30 healthy neonatus＇NO and TXB2 were detected as reference value.Results：In healthy neonatus,the level of NO was（62.5±14.7）μmol/L and TXB2 was（61.7±19.4）ng/L,which were obviously higher/lower than that of the 62 HIE neonatus respectively before therapy.NO increased and TXB2 decreased apparently and were close to the reference value in the observation group when therapy ended,and the level of NO and TXB2 in the observation group were statistically higher/lower than that of the control ones after therapy（P=0.024,0.021,respectively）.Pearson correlation analysis showed NO had a negative correlation with TXB2（r=-0.881,P=0.001）.Conclusions：RS injection could better help naloxone to increase the quantities of the NO and reduce TXB2 and thus could improve the disturbance of cerebral blood flow,which maybe a therapeutic mechanism of HIE.