阿昔洛韦治疗小儿水痘24例疗效观察

An Observation of Clinical Efficacy of Acyclovir in 24 Cases of Child Chickenpox

目的:探讨阿昔洛韦对小儿水痘的临床疗效及安全性。方法:46例水痘患儿随机分为两组,治疗组24例用阿昔洛韦5mg/(kg·次),每日4次口服,对照组22例用利巴韦林注射液10mg/(kg·d),每日静脉滴注一次,疗程均为5d,其他治疗方法相同。结果:治疗组热退及结痂时间较对照组缩短(P<0.05),差异有统计学意义,且两组治疗前后周围血白细胞和中性粒细胞比较差异无统计学意义(P>0.05)。结论:阿昔洛韦对小儿水痘有显著疗效,而且安全可靠。

Objective：To explore the clinical efficiency and safety of acyclovir in treating child chickenpox.Methods：Forty six cases of chickenpox were randomly divided into two groups.The treatment group（n=24）were treated with acyclovir of 5 mg/kg orally four times a day while the control group（n=22）with ribavirin of 10 mg/（kg·d）intravenously,once a day,with a course of 5 days for both groups.And the other treatments were the same.Results：The time of fever withdrawal and the scab in the treatment group was shorter than that of the control one（P0.05）.The peripheral blood leukocytes and neutrophils showed no significant difference before and after the treatment in two groups（P0.05）.Conclusions：There is a significant effect,safe and reliable for acyclovir to chickenpox in children.