儿童地高辛血药浓度监测及影响因素分析

The Therapeutic Drug Monitoring of Digoxin in Children and the Analysis of Influential Factor

目的:观察地高辛血药浓度监测对患儿个体化用药的作用。方法:应用化学发光免疫法(CLIA)测定地高辛血药浓度,并对结果进行分析。结果:161例患儿中在有效血药浓度范围内(0.8～2.0ng/mL)为79例(占49.1%),小于0.8ng/mL74例(占46.0%),大于2.0ng/mL8例(占4.9%)。结论:应从患儿个体的药效学、药动学出发,结合血药浓度监测及临床观察,在注重防止地高辛中毒反应的同时,使患儿的治疗达到有效、合理、安全。

Objective：To observe the importance of blood concentration monitoring in more individualized and rationalized administration of Digoxin.Methods：We performed the blood concentration monitoring of Digoxin by using chemiluminescent immunoassay and analyzed the results.Results：Among 161 child patients,there were 79 cases within the effective blood concentration（0.8～2.0 ng/mL）,accounted for 49.1%.There were 74 cases below 0.8 ng/mL,accounted for 46.0%,and 8 cases higher than 2.0 ng/mL accounted for 4.9%.Conclusions：We should consider the children＇s pharmacodynamics,pharmacokinetics,blood concentration monitoring and clinical observation to get the effect,rational and safe result and prevent the drug poisoning of digoxin.