厄贝沙坦氢氯噻嗪片对高血压患者左心室肥厚动脉顺应性的影响

Effect of Irbesartan Hydrochlorothiazide Tablets on Left Ventricular Hypertrophy Patients with Hypertension and Arterial Compliance

目的:探讨厄贝沙坦氢氯噻嗪片对高血压患者左心室肥厚、动脉顺应性的影响。方法:采用自身前后对照试验,对确诊原发性高血压的入选患者,给予口服厄贝沙坦氢氯噻嗪片,1片/d,并调整剂量或联合用药使其达到目标血压,疗程12个月。治疗前后用动态血压监测仪、彩色超声多普勒检测左室相关数据及颈动脉顺应性相关数据,并对结果进行分析。结果:治疗后血压明显下降,并达到目标血压,左心室舒张末期内径、左心室后壁与室间隔厚度显著下降(P≤0.05),动脉顺应性指标均较治疗前有明显改善(P<0.05)。结论:原发性高血压患者使用厄贝沙坦氢氯噻嗪片治疗12个月,可以逆转左心室肥厚,改善左室舒张功能,并能改善动脉的顺应性。

Objective：To explore the effect of irbesartan hydrochlorothiazide tablets on patients with hypertension left ventricular hypertrophy,arterial compliance.Method：Before and after the adoption of self-controlled trials,Selected pairs of patients diagnosed with primary hypertension,To give oral irbesartan hydrochlorothiazide tablets,1 tablet /day,And adjust the dose or combination therapy to achieve the target blood pressure,Course of 12 months.Before and after treatment with ambulatory blood pressure monitoring,color doppler detection of left ventricular and carotid artery compliance-related data relevant data,And the results are analyzed.Result：Blood pressure decreased significantly after treatment,And to achieve the target blood pressure,Left ventricular end diastolic diameter and Left ventricular posterior wall and interventricular septum thickness decreased significantly（P≤0.05）,Arterial compliance index than those before treatment a significant improvement in（P0.05）.Conclusion：Irbesartan in patients with essential hypertension hydrochlorothiazide tablets in treatment of 12 months,Reversible left ventricular hypertrophy,Improve left ventricular diastolic function,And to improve arterial compliance.