奥沙拉嗪联合蒙脱石散灌肠治疗溃疡性结肠炎疗效观察

The Treatment of Combination Olsalazine with Smectite Retention Enema on Ulcerative Colitis

目的:研究奥沙拉嗪联合蒙脱石散灌肠治疗活动期溃疡性结肠炎疗效。方法:将74例活动期左半溃疡性结肠炎患者分成联合灌肠组与对照组,每组均给予2.0g奥沙拉嗪,联合灌肠组灌肠液中加入1.0g蒙脱石散。每2周复查并记录大便性状、血生化检查、腹部体征以及症状变化,每4周复查结肠镜及病理组织学检查。结果:治疗8周后联合灌肠组30例显效(81.1%),对照组22例显效(59.5%),两组中未见无效病例。结论:奥沙拉嗪联合蒙脱石散灌肠治疗活动期左半溃疡性结肠炎疗效显著,增加了患者的依从性。

Objective：To compare the therapeutic effect difference on ulcerative colitis of retention enema combination olsalazine with smectite or not.Method：A total of 74 patients with active ulcerative colitis in left side were divided into combination retention enema group and placebo group,2.0g olsalazine were used in two groups,otherwise,1.0g smectite was mixed with clyster in combination retention enema group.Stool,blood biochemistry,the sign and symptom of ulcerative colitis were recorded every 2 weeks.The results of coloscopy and pathohistology were recorded every 4 weeks.Result：After 8 weeks therapy,there were 30 cases（81.1%） in combination group and 22 cases（59.5%） in placebo group showed excellent effect,no cases showed ineffective in two groups.Conclusion：To treat the left active ulcerative colitis,combination olsalazine with smectite retention enema is more effective than which without smectite.Olsalazine retention enema enhances compliance of the patients.