低分子肝素钙氯吡格雷治疗不稳定型心绞痛的疗效研究

Observation on the Effect of Low Molecular Heparin and Clopidogrel in Treating Patients with Unstable Angina Pectoris

目的:探讨低分子肝素钙(LMWH)、氯吡格雷治疗不稳定型心绞痛(UA)的临床效果。方法:将138例UA患者随机分为低分子肝素钙组、氯吡格雷组和对照组,三组均给予常规治疗,低分子肝素钙组同时给予LMWH皮下注射,氯吡格雷组同时给予氯吡格雷片口服。结果:三组患者用药后心绞痛改善情况:低分子肝素钙组疗效明显优于氯吡格雷组和对照组,两者分别比较差异具有统计学意义(P<0.05)。用药后心电图改善情况低分子肝素钙组疗效明显优于氯吡格雷组和对照组,两者分别比较差异具有统计学意义(P<0.05)。用药后低分子肝素钙组在TT、PT、APTT、Fbg改善方面明显优于氯吡格雷组和对照组,两者分别比较差异具有统计学意义(P<0.05)。结论:低分子肝素钙治疗不稳定型心绞痛疗效确切,副作用少,值得临床广泛应用。

Objective：To investigate the effect of low molecular heparin combined with clopidogrel in treating patients with unstable angina pectoris.Method：The 138 cases with unstable angina pectoris were divided into the low molecular heparin group clopidogrel group and control group.All of them received the treatment of normal ways,the low molecular heparin group received the treatment of low molecular heparin,and the clopidogrel group received the treatment of clopidogrel.Result：The improvement of angina in low molecular heparin group was superior to that in clopidogrel group and the control group,and there was significant difference in them respectively （P0.05）.The improvement of electrocardiogram in low molecular heparin group was superior to that in clopidogrel group and the control group,and there was significant difference in them respectively （P0.05）.The improvement of TT,PT,APTT and Fbg in low molecular heparin group was superior to that in clopidogrel group and the control group,and there was significant difference in them respectively （P0.05）.Conclusion：The effect of low molecular heparin in treating case with unstable angina pectoris is obvious,so they are worth being used widly.