梅尼埃病血清抗Ⅱ型胶原抗体的研究

Anti-Type Ⅱ Collagen Antibody in Theserum of Patients With Meniere's Disease

目的了解梅尼埃病与自身免疫之间的关系。方法测试了30例正常人和30例梅尼埃病患者血清中的非特异性免疫球蛋白（IgG、IgM和IgA），补体（C3和C4），以及抗Ⅱ型胶原抗体。结果梅尼埃病患者血清中非特异性IgG、IgM和IgA以及C3和C4均在正常范围；而患者中53．3％的抗Ⅱ型胶原抗体IgG明显增高，在正常对照组的血清中抗Ⅱ型胶原抗体均不增高。结论自身免疫反应可能是该病的原因之一。

Oubjective To know the relation between Meniere's disease and autoimmunity. MethodsThis study tested the unidiosyncratic immunoglobulins(IgC、IgM and IgA), complements(C3 and C4) and anti-type Ⅱ collagen antibody in each serum of the 3O normal persons and the 30 patients with Meniere's disease.Results The unidiosyncratic IgG、IgM and IgA and C3、C4 in the serum of patients with Meniere's diseasewere in a normal range.In 53.3% of the patients,the anti- type Ⅱ collagen antibody(IgG) was obviously in-creased. In the serum of normal subject,the anti- type Ⅱ collagen antibodies were not increased. ConclusionOne of the reasons caused Meniere's disease may be the autoimmunity.