摘要
目的:探讨血浆白介素-18(IL-18)、单核细胞趋化蛋白-1(MCP-1)同动脉硬化闭塞症的关系。方法:选择80例动脉硬化闭塞症(atherosclerosis obliterans,ASO)患者,利用ELISA法检测ASO治疗前后IL-18、MCP-1血浆水平。结果:ASO患者均存在高IL-18和高MCP-1血症,且与ASO严重程度密切相关;结果同时表明ASO有效治疗后血浆IL-18、MCP-1基本恢复正常。结论:IL-18、MCP-1同ASO的发生、发展密切相关,动态观察IL-18、MCP-1有助于判断治疗效果及有助于探讨ASO的治疗机制。
Objective: To investigate the relationship between atheroselerosis obliterans and IL-18 and MCP-1. Methods:The plasma IL-18 and MCP-1 levels were detected by ELISA in 80 cases of atherosclerosis obliterans before and after treatment. Results: The patients with atheroselerosis obliterans showed higher plasma IL--18 and MCP--1 levels, which was closely correlated with the severity of atherosclerosis obliterans. Conclusion: It is helpful to investigate the pathogenetic mechanism of atherosclerosis obliterans and to judge the therapeutic effectiveness of the disease by determining IL-18 and MCP-1.
出处
《黑龙江医药科学》
2010年第3期24-25,共2页
Heilongjiang Medicine and Pharmacy