心理应激在幽门螺杆菌感染胃黏膜过程中的作用

Effects of psychological stress in the pathogenesis of Helicobacter pylori infecting gastric mucosa

目的:探讨心理应激在幽门螺杆菌(helicobacter pylori,Hp)感染胃黏膜过程中的作用。方法:选用哥伦比亚培养基培养幽门螺杆菌并鉴定;40只小鼠随机分为双重因素组、单纯Hp组、单纯应激组、对照组,通过Hp菌液灌胃和电击造模,观察胃黏膜损伤情况。结果:双重因素组、单纯Hp组、单纯应激组与对照组胃黏膜炎症损伤评分比较,差异均有统计学意义(P<0.01);而Hp与心理应激在引起胃黏膜损伤中其协同作用显示无统计学意义(P=0.38)。结论:Hp、心理应激都可引起胃黏膜损伤,但两者在引起胃黏膜损伤的过程中是相互独立的因素。

Objective： To explore the effects of psychological stress in the pathogenesis of Helicobacter pylori（Hp） infecting gastric mucosa.Methods： Hp grew in Columbia medium and then was identified.Fifty mice were randomly divided into Hp＋ psychological stress group,Hp group,psychological stress group and control group.The models were given Hp liquid and electric shock,then observed the injury of gastric mucosa.Results： There was significant statistical difference between Hp＋ psychological stress group,Hp group,psychological stress group and control group in gastric mucosa inflammation（P0.01）,but there was no significant statistical difference in the cooperation of Hp and psychological stress（P=0.38）.Conclusion： Hp and psychological stress both took part in the injury of gastric mucosa,but they were two simple factors in the pathogenesis.