轻度认知障碍的中医证候分布规律研究

A Study on the Distribution Regularity of TCM Symptom and Sign in Mild Cognitive Impairment

目的:探讨轻度认知障碍(MCI)的中医临床证候分布特点与规律。方法:参照目前国际公认的MCI诊断标准,筛选出128例MCI患者,详细观察记录其中医临床症状,并根据规范化的辨证标准进行辨证分析。结果:MCI患者出现频率最高的前8种症状是:健忘善忘(近事遗忘)100%,膝腿酸软86.5%,二目昏花78.6%,头晕76.2%,耳鸣69.7%,发枯少华60.5%,少寐37.3%,精神萎靡28.1%;证候分布上髓海亏虚占94.5%:其中单纯虚证占59.3%;虚实夹杂证占35.2%(髓海亏虚兼痰浊者占21.9%,兼血瘀者占5.5%,兼痰浊及血瘀者占7.8%);单纯痰浊阻窍者占3.9%;单纯气滞血瘀者占1.6%。结论:MCI病位在脑,病性本虚标实,主要病机为肝肾亏虚,髓海不足,脑失所养,神明失用。

Objective ：To investigate the distribution character and regularity of TCM symptom and sign in mild cognitive impairment（MCI）. Methods： Refering to current international acknowledged diagnostic standard of MCI,128 patients with MCI-were screened,TCM clinical symptom were observed and recorded detailedly. Based on normative symptom differentiation stan-dard,syndrome-types were distinguished. Results： The first eight symptoms in order of appearing rates were： amnesia（ecmnesia）100%,leg limpness 86.5%,poor vision 78.6%,dizziness 76.2%,sonitus 69.7%,wizened hair 60.5%,insomnia 37.3%,listlessness 28.1%;as to the distribution of TCM symptom and sign： the ratio of deficiency of the marrow was 94.5%,in which simple deficiency syndrome was 59.3%,while syndrome of deficiency-excess complex was 35.2%（deficiency of the marrow accompanying with phlegm-turbidity was 21.9%;accompanying with blood stasis was 5.5%;accompanying with phlegm-turbidity and blood stasis was 7.8%）;simple phlegm-turbid obstruction of orifice was 3.9%;simple qi stagnation and blood stasis was 1.6%. Conclusion： There were obvious distribution regularity of TCM symptom and sign in MCI.