期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

胃癌组织中Claudin-7基因表达及临床意义 被引量：1

下载PDF
导出
摘要 目的探讨Claudin-7基因在胃癌发生、发展中的作用。方法采用原位杂交和免疫组化法检测45份胃癌组织(观察组)及10份正常胃黏膜组织(对照组)中Claudin-7基因的表达,并分析其与胃癌临床病理参数的关系。结果观察组及对照组Claudin-7蛋白阳性表达率分别为55.55%、100%,P<0.05;Claudin-7 mRNA阳性表达率分别为60%、100%,P<0.05。Claudin-7蛋白及Claudin-7 mRNA表达与胃癌组织肿瘤分化程度、浸润深度、淋巴结转移有关,而与性别、肿瘤大小无关。结论Claudin-7基因在胃癌组织中呈低表达,可促进胃癌的发生及发展。
作者 张俊会
机构地区 邢台医学高等专科学校
出处 《山东医药》 CAS 北大核心 2010年第19期99-100,共2页 Shandong Medical Journal
关键词 胃癌 Claudin-7 MRNA 原位杂交 免疫组织化学
分类号 R735.2 [医药卫生—肿瘤]
  • 相关文献

参考文献6

  • 1Almoustafa AE,Alaoui-Jamali MA,Batist G,et al.Identification of genes associated with head and neck carcinogenesis by cDNA microarray comparison between matched primary normal epithelial and squamous carcinoma cells[J].Oncogene,2002,21(17):2634-2640.
  • 2Kominsky SL,Argani P,Korz D,et al.Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast[J].Oncogene,2003,22(13):2021-2033.
  • 3贺德志,李建生,梁倩萍.食管鳞状细胞癌组织中Claudin-7和E-cadherin蛋白的表达[J].郑州大学学报（医学版）,2009,44(1):59-62. 被引量：1
  • 4Michl P,Barth C,Buchholz M,et al.Claudin-4 expression decreases invasiveness and metastatic potential of pancreatic cancer[J].Cancer Res,2003,63(19):6265-6271.
  • 5Hoevel T,Macek R,Swisshelm K,et al.Reexpression of the TJ protein CLDN1 induces apoptosis in breast tumor spheroids[J].Int J Cancer,2004,108(3):374-383.
  • 6Ikenouchi J,Matsuda M,Furuse M,et al.Regulation of tight junctions during the epithelium mesenchyme transition:directrepression of the gene expression of claudins/occludin by snail[J].J Cell Sci,2003,116(pt10):1959-1967.

二级参考文献14

  • 1付建华,杨达宽,黄云超,胡国强.表皮钙黏蛋白在食管癌组织中的表达及意义[J].西安交通大学学报（医学版）,2005,26(2):142-144. 被引量：1
  • 2Morin PJ. Claudin proteins in human cancer: promising new targets for diagnosis and therapy [ J ]. Cancer Res, 2005,65(21) :9 603.
  • 3Soini Y, Tommola S, Helin H,et al. Claudins 1, 3,4 and 5 in gastric carcinoma, loss of claudin expression associates with the diffuse subtype[ J]. Virehows Arch ,2006,448 (1):52.
  • 4Nakanishi Y, Ochiai A, Akimoto S, et al. Expression of E- cadherin,apha-catenin, beta-eatenin and plakoglobin in esophageal carcinomas and its prognostic significance: immunohistoehemieal analysis of 96 lesions [ J ]. Oneology, 1997,54(2) :158.
  • 5Hewitt KJ, Agarwal R, Morin PJ. The claudin gene family: expression in normal and neoplastic tissues [ J 1- BMC Cancer,2006,6 : 186.
  • 6Harhaj NS, Antonetti DA. Regulation of tight junctions and loss of barrier function in pathophysiology [ J ]. Int J Biochem Cell Biol,2004,36 ( 7 ) : 1 206.
  • 7Turksen K, Troy TC. Barriers built on claudins [ J ]. J Cell Sci,2004,117(Pt 12) :2 435.
  • 8Al Moustafa AE, Alaoui-Jamali MA, Batist G, et al. Identification of genes associated with head and neck carcino- genesis by cDNA microarray comparison between matched primary normal epithelial and squamous carcinoma cells [J]. Oncogene,2002,21(17):2634.
  • 9Kominsky SL, Argani P, Korz D, et al. Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast [J]. Oncogene,2003,22(13) :2 021.
  • 10Resnick MB, Konkin T, Routhier J, et al. Claudin-1 is a strong prognostic indicator in stage II colonic cancer: a tissue microarray study[ J]. Mod Pathol,2005,18 (4) :511.

同被引文献7

  • 1Kominsky SL, Argani P, Korz D, et al. Loss of the tight junction pro- tein claudin -7 correlates with histological grade in both ductal carcino- ma in situ and invasive ductal carcinoma of the breast [ J] . Oncogene, 2003, 22 (13) : 2 021 -2 033.
  • 2Al Moustafa AE, Alaoui -Jamali MA, Batist G, et al. Identification of genes associated with head and neck carcinogenesis by cDNA microarray comparison between matched primary normal epithelial and squamous carcinoma cells [J] . Oncogene, 2002, 21 (17) : 2 634 -2 640.
  • 3Swisshelm K, Macek R, Kubbies M. Role of claudins in tumorigenesis [J] . Adv Drug Deliv Rev, 2005, 57 (6) : 919 -928.
  • 4Morin PJ. Claudin proteins in human cancer: promising new targets for diagnosis and therapy [J] . Cancer Res, 2005, 65 (21) : 9 603 -9 606.
  • 5PARK D, KARESEN R, AXCRONAU, et al. Expression pattern of adhesionmolecules ( E - cadherin, alpha - , beta - , gamma - catenin and claudin- 7 ) their influence on survival in primary breast carcino- ma, and their corresponding axillary lymph node metastasis [ J ] .APMIS, 2007, 115 (1): 52-65.
  • 6Ishizaki T, Katsumata K, Tsuchida A, et al. Etodolac, a selective cy- clooxygenase-2 inhibitor, inhibits liver metastasis of colorectal cancer cells via the suppression of MMP - 9 activity [ J] . Int J Mol Med, 2006, 17 (2): 357-362.
  • 7杨彦林,张占学,宋伟庆,孙淑媛.结肠癌组织中p15、MMP-2、MMP-9的表达及意义[J].山东医药,2008,48(3):5-6. 被引量：4

引证文献1

二级引证文献2

山东医药
2010年 第19期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部