纤维蛋白止血敷料的止血效果

Hemostatic efficacy of fibrin dressing

目的评价纤维蛋白止血敷料对股动脉切口和肝脏损伤出血模型的止血效果。方法制造大鼠股动脉切口出血模型和兔肝脏损伤出血模型,分别用纤维蛋白止血敷料和医用胶原蛋白海绵进行止血,记录止血时间和出血量。结果对大鼠股动脉切口模型,纤维蛋白止血敷料止血时间为(90.60±33.12)s,出血量为(0.51±0.26)ml,医用胶原蛋白海绵止血时间为(164.20±53.70)s,出血量为(1.04±0.50)ml,二者差异有统计学意义(P<0.05);对兔肝损伤模型,纤维蛋白止血敷料止血时间为(48.67±8.14)s,出血量为(0.82±0.09)ml,医用胶原蛋白海绵止血时间为(107.67±6.66)s,出血量为(1.07±0.13)ml,二者差异有统计学意义(P<0.01)。结论纤维蛋白止血敷料的止血效果优于医用胶原蛋白海绵,是一种良好的止血材料。

Objective To evaluate the hemostatic efficacy of fibrin dressing in animal models of femoral artery transection and liver injury. Methods Fibrin dressing and collagen sponge were used in Wistar rat femoral artery incision and rabbit partial liver resections. The time to achieve complete hemostasis was recorded for each animal, as well as the blood loss. Results In femoral artery injury model, hemostasis occurred （90.60±33.12） s later in the fibrin dressing group, with the blood loss of （0.51±0.26） ml. In the collagen sponge group, hemostasis occurred （164.20±53.70） s later, with the blood loss of （1.04±0.50）ml. Statistical analysis showed significant difference between these two groups （P0.05）. In liver injury model, hemostasis occurred （48.67±8.14） s later in the fibrin dressing group, with blood loss of （0.82±0.09） ml. In the collagen sponge group, hemostasis occurred （107.67±6.66） s later, with the blood loss of （1.07±0.13） ml. Statistical analysis showed significant difference between these two groups （P0.05）. Conclusion The hemostatic effect of fibrin dressing is better than collagen sponge, and fibrin dressing is a good topical hemostatic .