安吉白茶多糖对实验性糖尿病小鼠的降血糖作用研究

Decreasing Effect of Polysaccharide in Anji White Tea on Blood Glucose in Tested Mice

通过制备去甲肾上腺素致糖尿病小鼠模型及四氧嘧啶致高血糖小鼠模型,给正常小鼠、去甲肾上腺素致高血糖小鼠及四氧嘧啶致糖尿病小鼠连续灌胃安吉白茶多糖14d后,取血测定血糖水平,以探讨安吉白茶多糖对正常小鼠、去甲肾上腺素致高血糖小鼠及四氧嘧啶致高血糖小鼠血糖水平及糖耐量(GT)的影响。结果显示,灌胃2周后,安吉白茶多糖对正常小鼠血糖水平影响较小,低、中、高剂量组与正常对照组相比均无显著意义(P>0.05);安吉白茶多糖能明显降低去甲肾上腺素所致糖尿病小鼠的血糖水平,低、中、高剂量组的血糖值与肾上腺素模型组比较,差异极显著(P<0.01)。且高剂量组降血糖效果优于低剂量组;安吉白茶多糖明显降低四氧嘧啶所致高血糖小鼠的血糖水平,三剂量组的血糖值与四氧嘧啶模型组比较,差异极显著(P<0.01)。三剂量均能降低实验性高血糖小鼠血糖,且随剂量增大,降血糖作用增强,以高剂量降糖作用最强。安吉白茶多糖在缓解糖尿病小鼠糖耐量降低方面作用显著,达到了药物组的治疗水平,但并不影响正常小鼠的血糖和糖耐量。

Prepare mice model with diabetes caused by reducing adrenaline and with hyperglycemia caused by tetraoxypyrimidine, after lavaging normal mice, mice model with diabetes caused by reducing adrenaline and with hyperglycemia caused by tetraoxypyrimidine for 14 days with Anji white tea polysaccharide, their blood sugar level are tested to study the effect of Anji white tea polysaccharide on the blood glucose. The result shows that after 2 weeks, Anji white tea polysaccharide showed a very weak effect on the blood glucose level of normal mice. Different dose showed small difference compared with normal dose （P〉0.05）, it can distinctly reduce the blood glucose level of mice models with diabetes caused by reducing adrenalin, the different doses showed quite different effects on their blood glucose levels（P〈0.01）, and the effect of high dose is distinctly better than that of low dose. It can effectively reduce the blood glucose level of the mice with hyperglycemia caused by tetraoxypyrimidine. The fasting glucose of the 3 groups with different doses are quite different from that with tetraoxypyrimidine （P〈0.01）. The 3 kind of doses can all reduce the blood glucose level of the tested mice, with a better effect by a larger dose. Anji white tea polysaccharide showed an effective influence on reducing the sugar tolerance of the mice with diabetes mellitus and has reached the cure level of the NAEDs, but it doesn’t affect the BSL and sugar tolerance of normal mice.