疏叶当归根的化学成分

The chemical constituents of root of Angelica laxifoliata Diels

从四川茂汶产的疏叶当归（ＡｎｇｅｌｉｃａｌａｘｉｆｏｌｉａｔａＤｉｅｌｓ）根的乙醇提取物中分离得９个化合物，鉴定了７个，分别为当归内酯（白芷内酯）（ａｎｇｅｌｉｃｉｎ，Ⅱ）、β谷甾醇（βｓｉｔｏｓｔｅｒｏｌ，Ⅲ）、β胡萝卜甙（βｄａｕｃｏｓｔｅｒｏｌ，Ⅳ）、二十八碳酸（ｎｏｃｔａｃｏｓａｎｏｉｃａｃｉｄ，Ⅴ）、蔗糖（ｓｕｃｒｏｓｅ，Ⅰ）、１０庚基１０辛基二十烷（１０ｈｅｐｔｙｌ１０ｏｃｔｙｌｅｉｃｏｓａｎｅ，Ⅵ）及疏叶香豆素（ｌａｘｉｆｏｌｉｎ，Ⅸ），其中疏叶香豆素为一新化合物，对钙拮抗有一定活性；另２个长链脂肪族化合物未鉴定。这９个化合物都是从该植物中首次分离得到。疏叶当归根的乙醚提取物，经气质联用分析得１０个挥发性成分，主含当归内酯（６５％），还含少量的δ（ｌ甲基乙基乙烯基）当归内酯〔δ（ｌｍｅｔｈｙｌｅｔｈｙｌｅｔｈｅｎｙｌ）２Ｈｆｕｒｏ（２，３ｈ）ｌｂｅｎｚｏｐｙｒａｎｅ２ｏｎｅ〕、９，１２十八碳二烯酸（９，１２ｏｃｔａｄｅｃａｄｉｅｎｏｉｃａｃｉｄ）、十六碳酸（ｈｅｘａｄｅｃａｎｏｉｃａｃｉｄ）、２甲基２丁烯酸（２ｍｅｔｈｙｌ２ｂｕ?

The root of Angelica laxifoliata Diels has been used as a folk medicine for the treatment of rheumatism and invigorating the circulation of blood in some areas in Sichuan Province. From the ethanol fraction of the root, 9 compounds have been isolated, 7 of them have elucidated as: angelicin (Ⅱ), β sitosterol (Ⅲ), β daucosterol (Ⅳ), n octacosanoic acid (Ⅴ), sucrose (Ⅰ), 10 heptyl 10 octyleicosane (Ⅵ) and laxifolin (Ⅸ),compound Ⅸ of them is a new constituent and revealed a calcium antagonistic action; the other 2 long chain fatty compounds were not identified. From the etherial extracts, 10 volatile constituents have obtained by GC MS methods and identified as angelicin (65%), small amount of δ (1 methylethylethenyl) 2H furo(2,3 h) 1 benzopyrane 2 one, 9,12 octadecadienoic acid, hexadecanoic acid, 2 methyl 2 butenoic acid and ethyl acetate etc.; 3 constituents were not identified.