铁箍散化学成分的研究

Studies on chemical constituents from Schisandra propinqua var.sinensis

目的:研究土家族药用植物铁箍散Schisandra propinqua var.sinensis根茎的化学成分。方法:采用硅胶柱色谱、凝胶柱色谱、制备高效液相色谱等方法分离化合物,根据理化性质和波谱解析鉴定各化合物的结构。结果:从铁箍散中分离鉴定了2个倍半萜(化合物1、2)和4个木脂素(化合物3～6),分别为泽泻醇(alismol,1)、匙叶桉油烯醇(ent-spathuleno l,2)、五味子酯I(schisantherin I,3)、五味子酯F(schisantherin F,4)、propinquanin A(5)、propinquanin D(6)。结论:化合物1～4为首次从该植物中分离得到。

Objective： To study the chemical constituents from Schisandra propinqua var. sinensis. Methods： The chemical comstituents were isolated by repeated column chromatography （Toyopearl HW-40C and HPLC） and their structures were elucidated on the basis of physico-chemical properties and spectroscopic features. Results： From the petroleum ether extract of the material, two sesquiterpene （compounds 1 and 2） and four lignan （compound 3--6） were isolated. Their structures were identified as： alismol （1）, ent-spathulenol （2）, schisantherin I （3）, schisantherin F （4）, propinquanin A （5）, and propinquanin D （6）. Conclusion： Compounds 1-4 are isolated from this plant for the first time.