药物肠道吸收研究方法

Methodology study of drug intestinal absorption

药物在肠道内的吸收程度和吸收特征是影响口服药物生物利用度的重要因素。肠道吸收研究可以预测影响药物在肠道吸收的机制与因素,研究方法主要包括体内法(invivo)、在体法(insitu)、体外法(invitro)等。就目前药物小肠吸收的研究方法及其特点进行综述。

The degree and character of intestinal tract absorption is an important factor that affects bioavailability of oral drugs.The absorption study of intestinal tract,including in vivo,in situ,in vitro,and so on,can predict mechanisms and factors that affect drug absorption in intestine.In this paper,the current methods of drug intestinal absorption and their characteristics are reviewed.