摘要
5-氨基-2,4,6-三碘异酞酰氯依次与2-异丙基-1,3-二氧六环-5-甲酰氯和3-甲氨基-1,2-丙二醇反应,再经水解,脱保护合成出碘比醇,并对其进行了结构表征.
Iobitridol was synthesized by two-step condensation reactions of 5-amino-2,4,6-triiodoisophthaloyl chloride with 2-isopropyl-1,3-dioxane-5-carboxylic acid chloride and 3-methylamino-1,2-propanediol in turn,followed by the de-protection through hydrolysis.The structures of Iobitridol and its intermediates were characterized by FT-IR,1H NMR and elemental analysis.
出处
《武汉工程大学学报》
CAS
2010年第5期25-27,30,共4页
Journal of Wuhan Institute of Technology
关键词
造影剂
碘比醇
合成
结构表征
contrast agent
iobitridol
synthesis
structural characterization
